Design of Outer Membrane Vesicles as Cancer Vaccines: A New Toolkit for Cancer Therapy.

ABSTRACT: Cancer vaccines have been extensively studied in recent years and have contributed to exceptional achievements in cancer treatment. They are some of the most newly developed vaccines, although only two are currently approved for use, Provenge and Talimogene laherparepvec (T-VEC). Despite the approval of these two vaccines, most vaccines have been terminated at the clinical trial stage, which indicates that although they are effective in theory, concerns still exist, including low antigenicity of targeting antigens and tumor heterogeneity. In recent years, with new understanding of the biological function and vaccine potential of outer membrane vesicles (OMVs), their potential application in cancer vaccine design deserves our attention. Therefore, this review focuses on the mechanisms, adva

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC6769604 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature