Hybrid Clustered Nanoparticles for Chemo-Antibacterial Combinatorial Cancer Therapy.

ABSTRACT: Background: A great number of therapeutic limitations, such as chemoresistance, high dosage, and long treatments, are still present in cancer therapy, and are often followed by side effects such as infections, which represent the primary cause of death among patients. Methods: We report pH- and enzymatic-responsive hybrid clustered nanoparticles (HC-NPs), composed of a PCL polymeric core loaded with an anticancer drug, such as Imatinib Mesylate (IM), and coated with biodegradable multilayers embedded with antibacterial and anticancer baby-ship silver NPs, as well as a monoclonal antibody for specific targeting of cancer cells conjugated on the surface. Results: The HC-NPs presented an onion-like structure that serially responded to endogenous stimuli. After internaliza

SUBMITTER: Cortese B 

PROVIDER: S-EPMC6769784 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature