Predicting cardiac electrical response to sodium-channel blockade and Brugada syndrome using polygenic risk scores.

ABSTRACT:

Aims

Sodium-channel blockers (SCBs) are associated with arrhythmia, but variability of cardiac electrical response remains unexplained. We sought to identify predictors of ajmaline-induced PR and QRS changes and Type I Brugada syndrome (BrS) electrocardiogram (ECG).

Methods and results

In 1368 patients that underwent ajmaline infusion for suspected BrS, we performed measurements of 26 721 ECGs, dose-response mixed modelling and genotyping. We calculated polygenic risk scores (PRS) for PR interval (PRSPR), QRS duration (PRSQRS), and Brugada syndrome (PRSBrS) derived from published genome-wide association studies and used regression analysis to identify predictors of ajmaline dose related PR change (slope) and QRS slope. We derived and validated using bootstrapping a predictiv

SUBMITTER: Tadros R 

PROVIDER: S-EPMC6769824 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature