Probiotic Supplementation is Associated with Increased Antioxidant Capacity and Copper Chelation in C. difficile-Infected Fecal Water.

ABSTRACT: Probiotic supplementation plays a key role in maintaining intestinal homeostasis due to its ability to modulate gut microbiota. Although their potential as potent antioxidants have previously been explored, their ability to affect the redox status in the gut lumen of healthy subjects or those with gastrointestinal (GI) disorders remains unclear. In our study, we assessed the ability of single strain and multispecies probiotic supplementation to cause a change in the redox status of normal fecal water and in Clostridium (C.) difficile-infected fecal water using a simulated gastrointestinal model. Changes in redox status were assessed by ferric-reducing antioxidant power (FRAP), 2',2'-diphenyl-1-picrylhydrazyl (DPPH), and iron and copper chelation assays. The findings from our study showed t

SUBMITTER: Gaisawat MB 

PROVIDER: S-EPMC6769851 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature