Design, Synthesis, and Anti-Bacterial Evaluation of Triazolyl-Pterostilbene Derivatives.

ABSTRACT: Staphylococcus aureus resistance to current antibiotics has become the greatest global challenge facing public health. The development of new antimicrobial agents is urgent and important and is needed to provide additional therapeutic options. In our previous study, we found out that pterostilbene exhibited potent antibacterial activity, especially against methicillin-resistant Staphylococcus aureus (MRSA). According to previous studies, 1,2,3-triazole, with the characteristic of increasing the interaction with the target readily and enhancing water solubility, were widely used in the approved anti-bacterial drugs. Therefore, these results attract our interest to use the structure of pterostilbene as a scaffold for the hybrid 1,2,3-triazole moiety to develop a novel anti-MRSA

SUBMITTER: Tang KW 

PROVIDER: S-EPMC6769857 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature