Capture and Detection of Circulating Glioma Cells Using the Recombinant VAR2CSA Malaria Protein.

ABSTRACT: Diffuse gliomas are the most common primary malignant brain tumor. Although extracranial metastases are rarely observed, recent studies have shown the presence of circulating tumor cells (CTCs) in the blood of glioma patients, confirming that a subset of tumor cells are capable of entering the circulation. The isolation and characterization of CTCs could provide a non-invasive method for repeated analysis of the mutational and phenotypic state of the tumor during the course of disease. However, the efficient detection of glioma CTCs has proven to be challenging due to the lack of consistently expressed tumor markers and high inter- and intra-tumor heterogeneity. Thus, for this field to progress, an omnipresent but specific marker of glioma CTCs is required. In this article, we demonstrate

SUBMITTER: Bang-Christensen SR 

PROVIDER: S-EPMC6769911 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature