Endoglin Protein Interactome Profiling Identifies TRIM21 and Galectin-3 as New Binding Partners.

ABSTRACT: Endoglin is a 180-kDa glycoprotein receptor primarily expressed by the vascular endothelium and involved in cardiovascular disease and cancer. Heterozygous mutations in the endoglin gene (ENG) cause hereditary hemorrhagic telangiectasia type 1, a vascular disease that presents with nasal and gastrointestinal bleeding, skin and mucosa telangiectases, and arteriovenous malformations in internal organs. A circulating form of endoglin (alias soluble endoglin, sEng), proteolytically released from the membrane-bound protein, has been observed in several inflammation-related pathological conditions and appears to contribute to endothelial dysfunction and cancer development through unknown mechanisms. Membrane-bound endoglin is an auxiliary component of the TGF-β receptor complex and the extracell

SUBMITTER: Gallardo-Vara E 

PROVIDER: S-EPMC6769930 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature