Forkhead Domains of FOXO Transcription Factors Differ in both Overall Conformation and Dynamics.

ABSTRACT: FOXO transcription factors regulate cellular homeostasis, longevity and response to stress. FOXO1 (also known as FKHR) is a key regulator of hepatic glucose production and lipid metabolism, and its specific inhibition may have beneficial effects on diabetic hyperglycemia by reducing hepatic glucose production. Moreover, all FOXO proteins are considered potential drug targets for drug resistance prevention in cancer therapy. However, the development of specific FOXO inhibitors requires a detailed understanding of structural differences between individual FOXO DNA-binding domains. The high-resolution structure of the DNA-binding domain of FOXO1 reported in this study and its comparison with structures of other FOXO proteins revealed differences in both their conformation and flexibility. The

SUBMITTER: Psenakova K 

PROVIDER: S-EPMC6770010 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature