Invariant Natural Killer T-Cells and Total CD1d Restricted Cells Differentially Influence Lipid Metabolism and Atherosclerosis in Low Density Receptor Deficient Mice.

ABSTRACT: Natural killer T (NKT) cells are a distinct subset of lymphocytes that bridge the innate and adaptive immune response and can be divided into type I invariant NKT cells (iNKT) and type II NKT cells. The objective of this study is to examine the effects of NKT cell on lipid metabolism and the initiation and progression of atherosclerosis in LDL receptor deficient (LDLR^-/-) mice. Mice were fed an atherogenic diet for 4 or 8 weeks and plasma lipids, lipoproteins, and atherosclerosis were measured. The selective absence of iNKT cells in Jα18^-/-LDLR^-/- mice led to an increase in plasma cholesterol levels in female mice. Transgenic Vα14tg/LDLR^-/- mice with elevated numbers of iNKT cells had increased late atherosclerosis of the innominate artery, thoug

SUBMITTER: VanderLaan PA 

PROVIDER: S-EPMC6770011 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature