Highlights in Resistance Mechanism Pathways for Combination Therapy.

ABSTRACT: Combination chemotherapy has been a mainstay in cancer treatment for the last 60 years. Although the mechanisms of action and signaling pathways affected by most treatments with single antineoplastic agents might be relatively well understood, most combinations remain poorly understood. This review presents the most common alterations of signaling pathways in response to cytotoxic and targeted anticancer drug treatments, with a discussion of how the knowledge of signaling pathways might support and orient the development of innovative strategies for anticancer combination therapy. The ultimate goal is to highlight possible strategies of chemotherapy combinations based on the signaling pathways associated with the resistance mechanisms against anticancer drugs to maximize the selective indu

SUBMITTER: Delou JMA 

PROVIDER: S-EPMC6770082 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature