BKCa (Slo) Channel Regulates Mitochondrial Function and Lifespan in Drosophila melanogaster.

ABSTRACT: BKCa channels, originally discovered in Drosophila melanogaster as slowpoke (slo), are recognized for their roles in cellular and organ physiology. Pharmacological approaches implicated BKCa channels in cellular and organ protection possibly for their ability to modulate mitochondrial function. However, the direct role of BKCa channels in regulating mitochondrial structure and function is not deciphered. Here, we demonstrate that BKCa channels are present in fly mitochondria, and slo mutants show structural and functional defects in mitochondria. slo mutants display an increase in reactive oxygen species and the modulation of ROS affected their survival. We also found that the absence of BKCa channels reduced the lifespan of Drosophila, and overexpression of human BKCa channels in flies ex

SUBMITTER: Gururaja Rao S 

PROVIDER: S-EPMC6770356 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature