Ontology highlight
ABSTRACT:
SUBMITTER: Sable R
PROVIDER: S-EPMC6770473 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
BioTechniques 20180901 3
Protein-protein interactions (PPI) by homo-, hetero- or oligo-merization in the cellular environment regulate cellular processes. PPI can be inhibited by antibodies, small molecules or peptides, and this inhibition has therapeutic value. A recently developed method, the proximity ligation assay (PLA), provides detection of PPI in the cellular environment. However, most applications using this assay are for proteins expressed in the same cell. We employ PLA for the first time to study PPI of cell ...[more]