Novel Human Bispecific Aptamer-Antibody Conjugates for Efficient Cancer Cell Killing.

ABSTRACT: Monoclonal antibodies have been approved by the Food and Drug Administration for the treatment of various human cancers. More recently, oligonucleotide aptamers have risen increasing attention for cancer therapy thanks to their low size (efficient tumor penetration) and lack of immunogenicity, even though the short half-life and lack of effector functions still hinder their clinical applications. Here, we demonstrate, for the first time, that two novel bispecific conjugates, consisting of an anti-epidermal growth factor receptor (EGFR) aptamer linked either with an anti-epidermal growth factor receptor 2 (ErbB2) compact antibody or with an immunomodulatory (anti-PD-L1) antibody, were easily and rapidly obtained. These novel aptamer-antibody conjugates retain the targeting ability of both t

SUBMITTER: Passariello M 

PROVIDER: S-EPMC6770524 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature