Dietary 25-Hydroxyvitamin D₃ Supplementation Alleviates Porcine Epidemic Diarrhea Virus Infection by Improving Intestinal Structure and Immune Response in Weaned Pigs.

ABSTRACT: We conducted this experiment to determine if feeding 25-hydroxyvitamin D₃ (25(OH)D₃) to weaned pigs would alleviate porcine epidemic diarrhea virus (PEDV) infection and immune response. Forty-two weaned pigs were allotted to 1 of 6 dietary 25(OH)D₃ treatments (5.5, 5.5, 43.0, 80.5, 118.0, 155.5 μg 25(OH)D₃/kg diet) for 26 days. On day 22 of the trial, all the treatments were orally administrated with PEDV except for one of the 5.5 μg 25(OH)D₃/kg treatments, which was challenged with the same volume of sterile saline and served as control. Another 5.5 μg 25(OH)D₃/kg group for PEDV challenge was named CON-PEDV. Average daily gain (p < 0.05) was reduced by PEDV infection. PEDV administration also induced severe diarrhea

SUBMITTER: Yang J 

PROVIDER: S-EPMC6770734 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature