A Model for the Homotypic Interaction between Na⁺,K⁺-ATPase β₁ Subunits Reveals the Role of Extracellular Residues 221-229 in Its Ig-Like Domain.

ABSTRACT: The Na⁺, K⁺-ATPase transports Na⁺ and K⁺ across the membrane of all animal cells. In addition to its ion transporting function, the Na⁺, K⁺-ATPase acts as a homotypic epithelial cell adhesion molecule via its β₁ subunit. The extracellular region of the Na⁺, K⁺-ATPase β₁ subunit includes a single globular immunoglobulin-like domain. We performed Molecular Dynamics simulations of the ectodomain of the β₁ subunit and a refined protein-protein docking prediction. Our results show that the β₁ subunit Ig-like domain maintains an independent structure and dimerizes in an antiparallel fashion. Analysis of the putative interface identified segment Lys221-Tyr229. We gen

SUBMITTER: Paez O 

PROVIDER: S-EPMC6770782 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature