How Does Pyridoxamine Inhibit the Formation of Advanced Glycation End Products? The Role of Its Primary Antioxidant Activity.

ABSTRACT: Pyridoxamine, one of the natural forms of vitamin B₆, is known to be an effective inhibitor of the formation of advanced glycation end products (AGEs), which are closely related to various human diseases. Pyridoxamine forms stable complexes with metal ions that catalyze the oxidative reactions taking place in the advanced stages of the protein glycation cascade. It also reacts with reactive carbonyl compounds generated as byproducts of protein glycation, thereby preventing further protein damage. We applied Density Functional Theory to study the primary antioxidant activity of pyridoxamine towards three oxygen-centered radicals (•OOH, •OOCH₃ and •OCH₃) to find out whether this activity may also play a crucial role in the context of protein glycation inhibit

SUBMITTER: Ramis R 

PROVIDER: S-EPMC6770850 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature