A Comprehensive Examination of Percutaneous Endoscopic Gastrostomy and Its Association with Amyotrophic Lateral Sclerosis Patient Outcomes.

ABSTRACT: There is literature discord regarding the impact of percutaneous endoscopic gastrostomy (PEG), or "feeding tube", on amyotrophic lateral sclerosis (ALS) outcomes. We assess one of the largest retrospective ALS cohorts to date (278 PEG users, 679 non-users). Kruskal-Wallis and Kaplan-Meier analysis compared cohort medians and survival duration trends. A meta-analysis determined the aggregate associative effect of PEG on survival duration by combining primary results with 7 published studies. Primary results (p < 0.001) and meta-analysis (p < 0.05) showed PEG usage is associated with an overall significant increase in ALS survival duration, regardless of onset type. Percent predicted forced vital capacity (FVC %predict) ≥50 at PEG insertion significantly increases survival duration (p < 0.00

SUBMITTER: Bond L 

PROVIDER: S-EPMC6770872 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature