Gene‒Prostate-Specific-Antigen-Guided Personalized Screening for Prostate Cancer.

ABSTRACT: (1) Background: A simulation approach for prostate cancer (PrCa) with a prostate-specific antigen (PSA) test incorporating genetic information provides a new avenue for the development of personalized screening for PrCa. Going by the evidence-based principle, we use the simulation method to evaluate the effectiveness of mortality reduction resulting from PSA screening and its utilization using a personalized screening regime as opposed to a universal screening program. (2) Methods: A six-state (normal, over-detected, low-grade, and high-grade PrCa in pre-clinical phase, and low-grade and high-grade PrCa in clinical phase) Markov model with genetic and PSA information was developed after a systematic review of genetic variant studies and dose-dependent PSA studies. This gene‒PSA-guided mode

SUBMITTER: Yang TK 

PROVIDER: S-EPMC6770934 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature