Allele-Specific Expression of CD4⁺ T Cells in Response to Marek's Disease Virus Infection.

ABSTRACT: Marek's disease (MD) is a T cell lymphoma disease induced by Marek's disease virus (MDV), a highly oncogenic α herpesvirus primarily affecting chickens. MD is a chronic infectious disease that threatens the poultry industry. However, the mechanisms of genetic resistance for MD are complex and not completely understood. In this study, to identify high-confidence candidate genes of MD genetic resistance, high throughput sequencing (RNA-seq) was used to obtain transcriptomic data of CD4⁺ T cells isolated from MDV-infected and non-infected groups of two reciprocal crosses of individuals mating by two highly inbred chicken lines (6₃ MD-resistant and 7₂ MD-susceptible). After RNA-seq analysis with two biological replicates in each group, we identified 61 and 123

SUBMITTER: Bai H 

PROVIDER: S-EPMC6770979 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature