Diverse Immunomodulatory Effects of Individual IFNα Subtypes on Virus-Specific CD8⁺ T Cell Responses.

ABSTRACT: Clinical administration of Interferon α (IFNα) resulted in limited therapeutic success against some viral infections. Immune modulation of CD8⁺ T cell responses during IFNα therapy is believed to play a pivotal role in promoting viral clearance. However, these clinical studies primarily focused on IFNα subtype 2. To date, the immunomodulatory roles of the remaining 10-13 IFNα subtypes remains poorly understood, thereby precluding assessments of their potential for more effective treatments. Here, we report that virus-specific CD8⁺ T cell responses were influenced to various extents by individual IFNα subtypes. IFNα4, 6, and 9 had the strongest effects on CD8⁺ T cells, including antiproliferative effects, improved cytokine production and cytotoxicity. Intere

SUBMITTER: Dickow J 

PROVIDER: S-EPMC6771563 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature