Burden of hereditary transthyretin amyloidosis on quality of life.

ABSTRACT:

Introduction

Hereditary transthyretin (hATTR) amyloidosis is a progressive, degenerative disease, with peripheral neuropathy, cardiomyopathy, and other clinical manifestations. In this study we examine the impact of hATTR amyloidosis on quality of life (QOL).

Methods

Neuropathy-specific QOL, measured with the Norfolk QOL-Diabetic Neuropathy questionnaire, was compared between patients with hATTR amyloidosis and patients with type 2 diabetes, whereas generic QOL, measured with the 36-item Short Form Health Survey version 2 (SF-36v2), was compared between patients with hATTR amyloidosis, the general population, and patients with chronic diseases.

Results

Neuropathy-specific QOL for patients with hATTR amyloidosis was nearly equivalent to that of patients with type 2 dia

SUBMITTER: Yarlas A 

PROVIDER: S-EPMC6771567 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature