Assessment of intravoxel incoherent motion MRI with an artificial capillary network: analysis of biexponential and phase-distribution models.

ABSTRACT:

Purpose

To systematically analyze intravoxel incoherent motion (IVIM) MRI in a perfusable capillary phantom closely matching the geometry of capillary beds in vivo and to compare the validity of the biexponential pseudo-diffusion and the recently introduced phase-distribution IVIM model.

Methods

IVIM-MRI was performed at 12 different flow rates ( 0.2⋯2.4mL/min ) in a capillary phantom using 4 different DW-MRI sequences (2 with monopolar and 2 with flow-compensated diffusion-gradient schemes, with up to 16 b values between 0 and 800s/mm2 ). Resulting parameters from the assessed IVIM models were compared to results from optical microscopy.

Results

The acquired data were best described by a static and a flowing compartment modeled by the phase-distribution approach. The

SUBMITTER: Schneider MJ 

PROVIDER: S-EPMC6771596 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature