Cyclic di-GMP inactivates T6SS and T4SS activity in Agrobacterium tumefaciens.

ABSTRACT: The Type VI secretion system (T6SS) is a bacterial nanomachine that delivers effector proteins into prokaryotic and eukaryotic preys. This secretion system has emerged as a key player in regulating the microbial diversity in a population. In the plant pathogen Agrobacterium tumefaciens, the signalling cascades regulating the activity of this secretion system are poorly understood. Here, we outline how the universal eubacterial second messenger cyclic di-GMP impacts the production of T6SS toxins and T6SS structural components. We demonstrate that this has a significant impact on the ability of the phytopathogen to compete with other bacterial species in vitro and in planta. Our results suggest that, as opposed to other bacteria, c-di-GMP turns down the T6SS in A. tumefaciens thus impacting

SUBMITTER: McCarthy RR 

PROVIDER: S-EPMC6771610 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature