T-cell-derived cytokines enhance the antigen-presenting capacity of human neutrophils.

ABSTRACT: Activated allergen-specific Th2 and Th1 cells release cytokines that transform neutrophils into functional APCs characterized by the expression of HLA-DR and CD58 as well as enhanced survival and antigen uptake, irrespectively of the presence of IL-10, which reduces allergen uptake by neutrophils.

SUBMITTER: Samadi N 

PROVIDER: S-EPMC6771661 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature