Autoimmune myocarditis is not associated with left ventricular systolic dysfunction.

ABSTRACT:

Background

Experimental autoimmune myocarditis (EAM) is a common animal model for the investigation of the pathophysiology of myocarditis. Because of diverging findings from previous studies, we performed serial echocardiographic examinations throughout the course of the disease and investigated the dimensions of the murine heart and left ventricular (LV) systolic function.

Materials and methods

Experimental autoimmune myocarditis was induced in male Balb/c mice by subcutaneous injection of a fragment of the α-myosin heavy chain (MyHC-α 614-629: Ac-SLKLMATLFSTYASAD). Transthoracic echocardiography was performed on days 0, 7 and 21 in healthy animals and mice with EAM.

Results

Experimental autoimmune myocarditis was associated with a reduction in LV systolic function a

SUBMITTER: Mirna M 

PROVIDER: S-EPMC6771695 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature