Quantification of hydroxyl exchange of D-Glucose at physiological conditions for optimization of glucoCEST MRI at 3, 7 and 9.4 Tesla.

ABSTRACT:

Aims

To determine individual glucose hydroxyl exchange rates at physiological conditions and use this information for numerical optimization of glucoCEST/CESL preparation. To give guidelines for in vivo glucoCEST/CESL measurement parameters at clinical and ultra-high field strengths.

Methods

Five glucose solution samples at different pH values were measured at 14.1 T at various B₁ power levels. Multi-B₁ -Z-spectra Bloch-McConnell fits at physiological pH were further improved by the fitting of Z-spectra of five pH values simultaneously. The obtained exchange rates were used in a six-pool Bloch-McConnell simulation including a tissue-like water pool and semi-solid MT pool with different CEST and CESL presaturation pulse trains. In vivo glucose injection

SUBMITTER: Zaiss M 

PROVIDER: S-EPMC6771698 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature