TWIST2: A new candidate tumor suppressor in prostate cancer.

ABSTRACT:

Background

Prostate cancer (PCa) is a leading cause of cancer morbidity and mortality in men worldwide; however, PCa incidence and mortality rates vary widely across geographic regions and ethnic groups. The current study was designed to elucidate the pivotal factors involved in PCa occurrence and development.

Methods

We performed RNA sequencing on the prostate tumor and adjacent normal tissues from Chinese PCa patients. Genes identified via genome-wide expression profile analysis were validated by quantitative reverse-transcription polymerase chain reaction and immunohistochemistry. Hypermethylation of CpG islands was assessed by nested methylation-specific PCR. Whole genome microarray analysis was performed using an Affymetrix GeneChip.

Results

We identified nine po

SUBMITTER: Zhao C 

PROVIDER: S-EPMC6771699 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature