Gray matter T1-w/T2-w ratios are higher in Alzheimer's disease.

ABSTRACT: Myelin determines the conduction of neuronal signals along axonal connections in networks of the brain. Loss of myelin integrity in neuronal circuits might result in cognitive decline in Alzheimer's disease (AD). Recently, the ratio of T1-weighted by T2-weighted MRI has been used as a proxy for myelin content in gray matter of the cortex. With this approach, we investigated whether AD dementia patients show lower cortical myelin content (i.e., a lower T1-w/T2-w ratio value). We selected structural T1-w and T2-w MR images of 293 AD patients and 172 participants with normal cognition (NC). T1-w/T2-w ratios were computed for the whole brain and within 90 automated anatomical labeling atlas regions using SPM12, compared between groups and correlated with the neuronal injury marker tau in cereb

SUBMITTER: Pelkmans W 

PROVIDER: S-EPMC6771703 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature