Trypanosoma brucei brucei causes a rapid and persistent influx of neutrophils in the spleen of infected mice.

ABSTRACT: Trypanosomosis is a chronic parasitic infection, affecting both humans and livestock. A common hallmark of experimental murine infections is the occurrence of inflammation and the associated remodelling of the spleen compartment. The latter involves the depletion of several lymphocyte populations, the induction of T-cell-mediated immune suppression, and the activation of monocyte/macrophage cell populations. Here, we show that in experimental T b brucei infections in mice, these changes are accompanied by the alteration of the spleen neutrophil compartment. Indeed, mature neutrophils are rapidly recruited to the spleen, and cell numbers remain elevated during the entire infection. Following the second peak of parasitemia, the neutrophil cell influx coincides with the rapid reduction of spl

SUBMITTER: Deleeuw V 

PROVIDER: S-EPMC6771705 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature