Contribution of acute infarcts to cerebral small vessel disease progression.

ABSTRACT:

Objective

To determine the contribution of acute infarcts, evidenced by diffusion-weighted imaging positive (DWI+) lesions, to progression of white matter hyperintensities (WMH) and other cerebral small vessel disease (SVD) markers.

Methods

We performed monthly 3T magnetic resonance imaging (MRI) for 10 consecutive months in 54 elderly individuals with SVD. MRI included high-resolution multishell DWI, and 3-dimensional fluid-attenuated inversion recovery, T1, and susceptibility-weighted imaging. We determined DWI+ lesion evolution, WMH progression rate (ml/mo), and number of incident lacunes and microbleeds, and calculated for each marker the proportion of progression explained by DWI+ lesions.

Results

We identified 39 DWI+ lesions on 21 of 472 DWI scans in 9 of 54 su

SUBMITTER: Ter Telgte A 

PROVIDER: S-EPMC6771732 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature