Peripheral mitochondrial function correlates with clinical severity in idiopathic Parkinson's disease.

ABSTRACT:

Background

Parkinson's disease is an intractable disorder with heterogeneous clinical presentation that may reflect different underlying pathogenic mechanisms. Surrogate indicators of pathogenic processes correlating with clinical measures may assist in better patient stratification. Mitochondrial function, which is impaired in and central to PD pathogenesis, may represent one such surrogate indicator.

Methods

Mitochondrial function was assessed by respirometry experiment in fibroblasts derived from idiopathic patients (n = 47) in normal conditions and in experimental settings that do not permit glycolysis and therefore force energy production through mitochondrial function. Respiratory parameters and clinical measures were correlated with bivariate analysis. Machine-learnin

SUBMITTER: Milanese C 

PROVIDER: S-EPMC6771759 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature