Building and Applying Quantitative Adverse Outcome Pathway Models for Chemical Hazard and Risk Assessment.

ABSTRACT: An important goal in toxicology is the development of new ways to increase the speed, accuracy, and applicability of chemical hazard and risk assessment approaches. A promising route is the integration of in vitro assays with biological pathway information. We examined how the adverse outcome pathway (AOP) framework can be used to develop pathway-based quantitative models useful for regulatory chemical safety assessment. By using AOPs as initial conceptual models and the AOP knowledge base as a source of data on key event relationships, different methods can be applied to develop computational quantitative AOP models (qAOPs) relevant for decision making. A qAOP model may not necessarily have the same structure as the AOP it is based on. Useful AOP modeling methods range from statistical, B

SUBMITTER: Perkins EJ 

PROVIDER: S-EPMC6771761 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature