Candidate genes of the transcellular and paracellular calcium absorption pathways in the small intestine of laying hens.

ABSTRACT: To meet the high calcium (Ca) demand during eggshell biomineralization (2 g of Ca per egg), laying hens develop specific metabolic regulations to maintain Ca homeostasis. The intake of Ca, its solubilization, and absorption capacity are enhanced at sexual maturity (SM). A better knowledge of the intestinal Ca transporters involved in their variations at this stage could indicate new nutritional strategies to enhance Ca digestive utilization. Transcellular Ca absorption pathway and its major player calbindin-D 28 K (CALB1) mediate a saturable transport, which has been extensively described in this model. Conversely, a contribution by the paracellular pathway involving non-saturable Ca transport through intercellular tight junction has also been suggested. The aim of the present study was to

SUBMITTER: Gloux A 

PROVIDER: S-EPMC6771766 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature