Lung function in school-aged congenital diaphragmatic hernia patients; a longitudinal evaluation.

ABSTRACT:

Objective

Children with congenital diaphragmatic hernia (CDH) are at risk for pulmonary morbidity. Data on longitudinal evaluation of lung function in CDH are scarce. We hypothesized that CDH patients would have impaired lung function that worsens over time. We evaluated lung function and its determinants at ages 8 and 12 years.

Methods

Dynamic and static lung volumes, and diffusion capacity were measured. Extracorporeal membrane oxygenation (ECMO) treatment, the standardized European neonatal treatment protocol, patch repair, duration of ventilation, type of initial mechanical ventilation, and nitric oxide treatment were entered as covariates in linear mixed models with standard deviation score (SDS) lung function parameters (FEV₁ , FEF _25-75 , and K <

SUBMITTER: Toussaint-Duyster LCC 

PROVIDER: S-EPMC6771804 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature