Neuronal input triggers Ca²⁺ influx through AMPA receptors and voltage-gated Ca²⁺ channels in oligodendrocytes.

ABSTRACT: Communication between neurons and developing oligodendrocytes (OLs) leading to OL Ca²⁺ rise is critical for axon myelination and OL development. Here, we investigate signaling factors and sources of Ca²⁺ rise in OLs in the mouse brainstem. Glutamate puff or axon fiber stimulation induces a Ca²⁺ rise in pre-myelinating OLs, which is primarily mediated by Ca²⁺ -permeable AMPA receptors. During glutamate application, inward currents via AMPA receptors and elevated extracellular K⁺ caused by increased neuronal activity collectively lead to OL depolarization, triggering Ca²⁺ influx via P/Q- and L-type voltage-gated Ca²⁺ (Ca_v ) channels. Thus, glutamate is a key signaling factor in dynamic communication betwe

SUBMITTER: Barron T 

PROVIDER: S-EPMC6771819 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature