Biophysically motivated efficient estimation of the spatially isotropic R2* component from a single gradient-recalled echo measurement.

ABSTRACT:

Purpose

To propose and validate an efficient method, based on a biophysically motivated signal model, for removing the orientation-dependent part of R2* using a single gradient-recalled echo (GRE) measurement.

Methods

The proposed method utilized a temporal second-order approximation of the hollow-cylinder-fiber model, in which the parameter describing the linear signal decay corresponded to the orientation-independent part of R2* . The estimated parameters were compared to the classical, mono-exponential decay model for R2* in a sample of an ex vivo human optic chiasm (OC). The OC was measured at 16 distinct orientations relative to the external magnetic field using GRE at 7T. To show that the proposed signal model can remove the orientation dependence of R2* , it was compa

SUBMITTER: Papazoglou S 

PROVIDER: S-EPMC6771860 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature