Phenotypic factors associated with amisulpride-induced weight gain in first-episode psychosis patients (from the OPTiMiSE cohort).

ABSTRACT:

Objective

Antipsychotic-induced weight gain (AiWG) is a debilitating adverse effect of most antipsychotics. First-episode psychosis patients are particularly vulnerable to the detrimental consequences of AiWG. Amisulpride has good efficacy and tolerability. We here aimed to identify the phenotypic factors associated with amisulpride-induced weight gain in first-episode psychosis patients.

Method

Data were collected from the Optimization of Treatment and Management of Schizophrenia in Europe trial. Multivariable regression models with various phenotypic variables (N = 305) were performed with absolute AiWG and clinically relevant AiWG (≥7% AiWG) as outcomes.

Results

Four weeks of amisulpride treatment increased body weight from 69.7 to 72.4 kg (P < 0.001). In the regre

SUBMITTER: Pandit R 

PROVIDER: S-EPMC6771865 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature