Evaluation of the spatial variability in the major resting-state networks across human brain functional atlases.

ABSTRACT: The human brain is intrinsically organized into resting-state networks (RSNs). Currently, several human brain functional atlases are used to define the spatial constituents of these RSNs. However, there are significant concerns about interatlas variability. In response, we undertook a quantitative comparison of the five major RSNs (default mode [DMN], salience, central executive, sensorimotor, and visual networks) across currently available brain functional atlases (n = 6) in which we demonstrated that (a) similarity between atlases was modest and positively linked to the size of the sample used to construct them; (b) across atlases, spatial overlap among major RSNs ranged between 17 and 76% (mean = 39%), which resulted in variability in their functional connectivity; (c) lower order RSNs

SUBMITTER: Doucet GE 

PROVIDER: S-EPMC6771873 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature