3D nonrigid motion correction for quantitative assessment of hepatic lesions in DCE-MRI.

ABSTRACT:

Purpose

To provide nonrigid respiratory motion-corrected DCE-MRI images with isotropic resolution of 1.5 mm, full coverage of abdomen, and covering the entire uptake curve with a temporal resolution of 6 seconds, for the quantitative assessment of hepatic lesions.

Methods

3D DCE-MRI data were acquired at 3 T during free breathing for 5 minutes using a 3D T₁ -weighted golden-angle radial phase-encoding sequence. Nonrigid respiratory motion information was extracted and used in motion-corrected image reconstruction to obtain high-quality DCE-MRI images with temporal resolution of 6 seconds and isotropic resolution of 1.5 mm. An extended Tofts model was fitted to the dynamic data sets, yielding quantitative parametric maps of endothelial permeability using the hepati

SUBMITTER: Ippoliti M 

PROVIDER: S-EPMC6771884 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature