Partial volume correction for quantitative CEST imaging of acute ischemic stroke.

ABSTRACT:

Purpose

Contributions of cerebrospinal fluid (CSF) have not been previously taken into account in the quantification of APT CEST effects, and correction for the dilution of CEST effects by CSF may allow for more robust measurement of CEST signals. The objective of this study was to compare the robustness of a partial volume (PV) correction model against a standard (4-pool) multi-pool model as far as their ability to quantify CEST effects in healthy, normal, and pathological tissue.

Methods

MRI data from 12 patients presenting with ischemic stroke, and 6 healthy subjects, were retrospectively analyzed. CEST signals derived from a 4-pool model and a PV correction model were compared for repeatability and pathological tissue contrast. The effect of PV correction (PVC) was asses

SUBMITTER: Msayib Y 

PROVIDER: S-EPMC6771886 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature