Effects of common genetic variants associated with colorectal cancer risk on survival outcomes after diagnosis: A large population-based cohort study.

ABSTRACT: Genome-wide association studies have thus far identified 130 genetic variants linked to colorectal cancer (CRC) risk (r²  < 0.2). Given their implication in disease causation, and thus plausible biologically effects on cancer-relevant biological pathways, we investigated whether these variants are associated with CRC prognosis and also whether they might provide predictive value for survival outcome. We conducted the analysis in a well-characterized population-based study of 5,675 patients after CRC diagnosis in Scotland. None of the genetic risk variants were associated with either overall survival (OS) or CRC-specific survival. Next, we combined the variants in a polygenic risk score, but again we observed no association between survival outcome and overall genetic susceptibil

SUBMITTER: He Y 

PROVIDER: S-EPMC6771941 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature