Impact of Weight Loss Strategies on Obesity-Induced DNA Damage.

ABSTRACT:

Scope

Obesity causes DNA damage, which is causally related to several disorders including cancer, infertility, and cognitive dysfunctions. The aim of this study is to investigate whether weight loss improves the integrity of the genetic material.

Methods and results

Overweight mice are fed ad libitum either with a Western diet (WD), with a 40% caloric restricted WD, or with a high carbohydrate low protein (HCLP) diet. Caloric restriction and also the HCLP diet lead to ca. 30% weight loss, which is paralleled by decreased DNA damage ("comet" formation) and oxidative damage of purines in inner organs, additionally the activity of nucleotide excision repair increased. The effects are more pronounced in animals that have received the HCLP chow. Results of biochemical analyses in

SUBMITTER: Setayesh T 

PROVIDER: S-EPMC6771950 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature