A clinal polymorphism in the insulin signaling transcription factor foxo contributes to life-history adaptation in Drosophila.

ABSTRACT: A fundamental aim of adaptation genomics is to identify polymorphisms that underpin variation in fitness traits. In Drosophila melanogaster, latitudinal life-history clines exist on multiple continents and make an excellent system for dissecting the genetics of adaptation. We have previously identified numerous clinal single-nucleotide polymorphism in insulin/insulin-like growth factor signaling (IIS), a pathway known from mutant studies to affect life history. However, the effects of natural variants in this pathway remain poorly understood. Here we investigate how two clinal alternative alleles at foxo, a transcriptional effector of IIS, affect fitness components (viability, size, starvation resistance, fat content). We assessed this polymorphism from the North American cline by reconsti

SUBMITTER: Durmaz E 

PROVIDER: S-EPMC6771989 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature