Peptide and non-peptide mimetics as potential therapeutics targeting oral bacteria and oral biofilms.

ABSTRACT: The development of the oral biofilm requires a complex series of interactions between host tissues and the colonizing bacteria as well as numerous interspecies interactions between the organisms themselves. Disruption of normal host-microbe homoeostasis in the oral cavity can lead to a dysbiotic microbial community that contributes to caries or periodontal disease. A variety of approaches have been pursued to develop novel potential therapeutics that are active against the oral biofilm and/or target specific oral bacteria. The structure and function of naturally occurring antimicrobial peptides from oral tissues and secretions as well as external sources such as frog skin secretions have been exploited to develop numerous peptide mimetics and small molecule peptidomimetics that show improv

SUBMITTER: Sztukowska MN 

PROVIDER: S-EPMC6772003 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature