Volume-localized measurement of oxygen extraction fraction in the brain using MRI.

ABSTRACT:

Purpose

T₂ -relaxation-under-spin-tagging (TRUST) is an MR technique for the non-invasive assessment of whole-brain cerebral oxygen extraction fraction (OEF), through measurement of the venous blood T₂ relaxation time in the sagittal sinus. A key limitation of TRUST, however, is the lack of spatial specificity of the measurement. We sought to develop a modified TRUST sequence, selective localized TRUST (SL-TRUST), having sensitivity to venous blood T₂ within a targeted brain region, and therefore achieving spatially localized measurements of cerebral tissue OEF, while still retaining acquisition in the sagittal sinus.

Methods

A method for selective localization of TRUST sequence was developed, and the reproducibility of the technique was eval

SUBMITTER: O'Brien C 

PROVIDER: S-EPMC6772021 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature