A systematic review and meta-analysis of clinical predictors of lithium response in bipolar disorder.

ABSTRACT:

Objective

To determine clinical predictors of lithium response in bipolar disorder.

Methods

Systematic review of studies examining clinical predictors of lithium response was conducted. Meta-analyses were performed when ≥2 studies examined the same potential predictor.

Results

A total of 71 studies, including over 12 000 patients, identified six predictors of good response: mania-depression-interval sequence [odds ratio (OR): 4.27; 95% CI: 2.61, 6.97; P < 0.001], absence of rapid cycling (OR for rapid cycling: 0.30; 95% CI: 0.17, 0.53; P < 0.001), absence of psychotic symptoms (OR for psychotic symptoms: 0.52; 95% CI: 0.34, 0.79; P = 0.002), family history of bipolar disorder (OR: 1.61; 95% CI: 1.03, 2.52; P = 0.036), shorter prelithium illness duration [standardised

SUBMITTER: Hui TP 

PROVIDER: S-EPMC6772083 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature