Divergent memory responses driven by adenoviral vectors are impacted by epitope competition.

ABSTRACT: Adenoviral vectors induce robust epitope-specific CD8⁺ T cell responses. Within the repertoire of responses generated both conventional memory evolution and the phenomenon of memory inflation are seen. The rules governing which epitopes inflate are not fully known, but may include a role for both antigen processing and competition. To investigate this, we looked at memory generated from vectors targeting the Gp33-41 (KAVYNFATC/K9C) epitope from the gp of lymphocytic choriomeningitis virus (LCMV) in mice. This well-described epitope has both the Gp33-41 and Gp34-41 epitopes embedded within it. Vaccination with a full-length gp or a minigene Ad-Gp33/K9C vector-induced conventional memory responses against the immunodominant Gp33/K9C epitope but a strong inflationary response again

SUBMITTER: Colston JM 

PROVIDER: S-EPMC6772135 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature