C-Terminal alternative splicing changes the gating properties of a human spinal cord calcium channel alpha 1A subunit.

ABSTRACT: The calcium channel alpha(1A) subunit gene codes for proteins with diverse structure and function. This diversity may be important for fine tuning neurotransmitter release at central and peripheral synapses. The alpha(1A) C terminus, which serves a critical role in processing information from intracellular signaling molecules, is capable of undergoing extensive alternative splicing. The purpose of this study was to determine the extent to which C-terminal alternative splicing affects some of the fundamental biophysical properties of alpha(1A) subunits. Specifically, the biophysical properties of two alternatively spliced alpha(1A) subunits were compared. One variant was identical to an isoform identified previously in human brain, and the other was a novel isoform isolated from human spina

SUBMITTER: Krovetz HS 

PROVIDER: S-EPMC6772849 | biostudies-literature | 2000 Oct

REPOSITORIES: biostudies-literature