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Site-Selective, Remote sp3 C-H Carboxylation Enabled by the Merger of Photoredox and Nickel Catalysis.


ABSTRACT: A photoinduced carboxylation of alkyl halides with CO2 at remote sp3 C-H sites enabled by the merger of photoredox and Ni catalysis is described. This protocol features a predictable reactivity and site selectivity that can be modulated by the ligand backbone. Preliminary studies reinforce a rationale based on a dynamic displacement of the catalyst throughout the alkyl side chain.

SUBMITTER: Sahoo B 

PROVIDER: S-EPMC6773098 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Site-Selective, Remote sp<sup>3</sup> C-H Carboxylation Enabled by the Merger of Photoredox and Nickel Catalysis.

Sahoo Basudev B   Bellotti Peter P   Juliá-Hernández Francisco F   Meng Qing-Yuan QY   Crespi Stefano S   König Burkhard B   Martin Ruben R  

Chemistry (Weinheim an der Bergstrasse, Germany) 20190606 38


A photoinduced carboxylation of alkyl halides with CO<sub>2</sub> at remote sp<sup>3</sup> C-H sites enabled by the merger of photoredox and Ni catalysis is described. This protocol features a predictable reactivity and site selectivity that can be modulated by the ligand backbone. Preliminary studies reinforce a rationale based on a dynamic displacement of the catalyst throughout the alkyl side chain. ...[more]

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