Neurodevelopmental disorders among term infants exposed to antenatal corticosteroids during pregnancy: a population-based study.

ABSTRACT:

Objective

An increasing proportion of fetuses are exposed to antenatal corticosteroids (ACS). Despite their immediate beneficial effects, the long-term safety of ACS has been an ongoing source of concern. In the current study, we assessed the likelihood of neurodevelopmental problems among term infants exposed to ACS earlier in pregnancy compared with non-exposed term infants.

Design

Retrospective cohort study (2006-2011). Median duration of follow-up was 7.8 (IQR 6.4-9.2) years.

Setting

Population-based study, Ontario, Canada.

Participants

All live singleton infants born at term (≥37^0/7 weeks gestation) (n=529 205).

Exposure

ACS during pregnancy.

Primary and secondary outcome measures

A composite of diagnostic or billing codes reflecti

SUBMITTER: Melamed N 

PROVIDER: S-EPMC6773295 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature